If you want the best fresh seafood on your trip get off I 95 at Exit 49 in Darien, GA to the right a

It would also help if we knew (1) what time of the year you're traveling, (2) who are the "we" doing this and, if children, their approximate denver hotels ages, (3) how long you plan to take while doing this trip, and (4) your budget.
All those require you to leave I-95, but they are all on your way. If you got off in Savannah and drove to Charleston on US 17, you would see a good bit of the above. You could spend a night in Savannah and maybe two in Charleston. When in Williamsburg, be sure to visit Jamestown as well.
Richmond, Frederickburg, Savannah, Charleston, Appamatox, Bentonville, Willmington, battleship North Carolina, naval vessels at Patriot Point, CSS Hunley, Camp le Jeune, the battlefields of the Wilderness Campaign.
Here's some places to stop and rest. When you get to Jacksonville, FL on I 95 get off at Exit 353 C on W Union St. and go about 8 blocks to Pearl and take a left to Jenkin's Quality BBQ which is home owned by the Jenkins' Family for over 50 years. Get off I 95 at Exit 373 and go W to Callahan's BBQ.
Get off I 95 at Exit 1 and go W on St. Mary's which turns into Scrubby Bluff Rd. and go to Jack's BBQ. Or you can get off I 95 at Exit 3 at Kingsland, GA and cross E King Ave. to Boone Ave. which is the next street then take a left to Blue's BBQ at the Chevron Market for good BBQ.
If you want the best fresh seafood on your trip get off I 95 at Exit 49 in Darien, GA to the right and go E on Highway 251 to Highway 17. Take a right on Highway 17 and go S for 1.2 miles. Turn right on Broad St. just before crossing the bridge. Go one block and take your first left on Screven St. and have some outstanding fresh seafood at Skipper's Fish Camp. [size=3 font="times new roman"].
Get off I 95 at Exit 58 at Townsend, GA to the right on Highway 99 and go less than a mile to Highway 17. Turn left and go N about 2 miles to Pine Harbor Rd. Take a right and go E about 2 miles to Sepelo Station Crossing and fantastic fresh local seafood and hand cut steaks.
Get off I 95 at Exit 67 at Townsend, GA to the right and go S on Highway 17 for 1.2 miles then take a left going E onto Harris Neck Road just past a small church. denver hotels Go 5.7 miles E to the Jessie Grant Road and look for the purple OSD sign on your left. Turn to the right at the sign for about 100 feet to Old School Diner for the best fresh seafood around. OSD is open for dinner Wednesday/Saturday and Noon to 10 PM on Sunday. They are closed on Monday and Tuesday. This might be the best road food you will have on your trip.
Get off I 95 at Exit 76 at Midway, GA and go E on Highway 38 to Sunbury Rd. Take a left and go to Brigantine Dunmore Rd. Take a left and go to Sunbury Crab Co. which is open for dinner serving denver hotels outstanding fresh seafood. This might be the best place you stop for the seafood is outstanding.
Get off I 95 at Exit 87 at Richmond Hill, GA and go W on Highway 17 half a mile to Smoking Pig BBQ next to the BP Station on N side of Highway 17. The ribs and chicken are excellent. This is probably your best stop for BBQ in GA.
Get off I 95 at Exit 5 at Hardeville, SC and go S on Highway 17 which is Speedway Boulevard. Go 5.5 miles and take a left on Highway 170A which is S 27 34 and go 3.5 miles to Oakatie Highway. Take a right and go to The Pink Pig.
Get off I95 at Exit 21 at Ridgeland, SC and go E on Grahamville Road to State Road S/27/13 and take a right. Take your next left and go to The Old House Smokehouse on Highway 336 or Old House Road for good steaks and seafood. Get off I 95 at Exit 21 at Ridgeland, SC and have great pulled or chopped port at BBQ Grill. They also have BBQ ribs and chicken. I think it's better than Dukes.
denver hotels Get off I 95 at Exit 98 at Santee, SC and go W on Highway 6 to the 1st street on your left which is Britain. Turn left and go to Maurice's for good BBQ. Get off I 95 at Exit 98 and go W on Highway 6. Take a right on State Park Road and go to Lonestar BBQ for good southern food. Clark's Inn and Restaurant is a very fine place to spend the night and have breakfast, lunch or dinner.
Get off I 95 at Exit 160 A going S at Florence, SC and go E on # 20 less than a mile to Red Bone Alley in Florence Mall Shopping Center on Palmetto St. for a RBA Black and Bleu Burger or a Bubba Burger. Or go to Apple Annie's for good road food.
Get off I 95 at Exit 181A and go one mile to Highway 917. Take a left and go about 3 miles to Abingdon Manor Inn and Restaurant at Latta, SC. Spend the night in a soft bed in a grand old inn and have a fantastic dinner.
Get off I 95 at Exit 20 in Lumberton, NC to the right then turn NW on Highway 201 which is N Roberts Ave. and go about half a mile to Fuller's BBQ for good road food. Or get off at Exit 22 and go to Nelson s for good BBQ. I think Nelson s is the best.
At Exit 73 in Dunn, NC get off I 95 going W on Cumberland go about a mile take a right on General Lee and next left on Broad for some fine fried chicken at Kim's. Don't let the name bother denver hotels you. They sell a BBQ sandwich but 99% country food.
For outstanding BBQ and country fried chicken get off I 95 at Exit 79 at Benson, NC and go W on E Main Street to N Fayetteville Street denver hotels which is the first street to your right. Take a right and go N to E Church Street. Take a right and go to N Honeycutt Street. White Swan will be on your left.
Take Exit 138 off I 95 at Rocky Mt., NC and go E on I 64 for 1 1/2 miles to Exit 466 and go S on N Winstead Ave. to Sunset Ave. Take a right and go to Gardner's BBQ. Gardner's has 3 locations in Rocky Mt., NC but this one on Sunset is the most convenient to I 95. You will pass a Hampton Inn on your right when you exit I 64 if you are planning to spend the night in Rocky Mt., NC.
A few miles N of Richmond, VA get of I 95 at Exit 92 and go E on E Patrick Henry Road or Highway 54. Go 1.4 miles to N Center Street and turn right. Go .1 mile to Henry Clay Road and turn left. Then Immediately turn left on N Railroad Ave and go .1 mile to Henry Clay Inn for the night. They have fourteen rooms that run $95.00/$195.00 per night. You can walk S on Railroad to the next block for outstanding lunch or dinner at Iron Horse Restaurant.
Get off I 95 at Exit 130 B at Fredericksburg, VA and go E on Highway 3 to Jefferson Davis Highway # 1. Take a left and go N to Allman's BBQ in front of Park and Shop shopping center. You will find good BBQ since 1954.